887 citations · 2k across the 14 of their papers we have counts for
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Modeling and interpretation of single-cell proteogenomic data
Andrew Leduc, Hannah Harens, Nikolai Slavov
Biological functions stem from coordinated interactions among proteins, nucleic acids and small molecules. Mass spectrometry technologies for reliable, high throughput single-cell…
Mass-spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation
Bogdan Budnik, Ezra Levy, Guillaume Harmange +1
Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of e…
Routinely quantifying single cell proteomes: A new age in quantitative biology and medicine
Harrison Specht, Nikolai Slavov
Many pressing medical challenges - such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers - have long been hindered by limitations in our…
Post-transcriptional regulation across human tissues
Alexander Franks, Edoardo Airoldi, Nikolai Slavov
Transcriptional and post-transcriptional regulation shape tissue-type-specific proteomes, but their relative contributions remain contested. Estimates of the factors determining pr…
Extensive regulation of metabolism and growth during the cell division cycle
Nikolai Slavov, David Botstein, Amy Caudy
Yeast cells grown in culture can spontaneously synchronize their respiration, metabolism, gene expression and cell division. Such metabolic oscillations in synchronized cultures re…
Differential stoichiometry among core ribosomal proteins
Nikolai Slavov, Sefan Semrau, Edoardo Airoldi +2
Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its deregulation in disease. While ribosomes are believed to have a fixe…