82 citations · 119 across the 6 of their papers we have counts for
6 papers
Kinetics of seeded protein aggregation: theory and application
Alexander J. Dear, Georg Meisl, Jing Hu +2
``Seeding'' is the addition of preformed fibrils to a solution of monomeric protein to accelerate its aggregation into new fibrils. It is a versatile and widely-used tool for scien…
Competing addition processes give distinct growth regimes in the assembly of 1D filaments
Sk Ashif Akram, Tyler Brown, Stephen Whitelam +3
We present a model to describe the concentration-dependent growth of protein filaments. Our model contains two states, a low entropy/high affinity ordered state and a high entropy/…
General integrated rate law for complex self-assembly reactions reveals the mechanism of amyloid-beta co-aggregation
Alexander J. Dear, Georg Meisl, Emil Axell +5
Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyl…
The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases
Travis B. Thompson, Georg Meisl, Tuomas Knowles +1
Protein aggregates in the brain play a central role in cognitive decline and structural damage associated with neurodegenerative diseases. For instance, in Alzheimer's disease the…
Mechanism, scaling and rates of protein aggregation from in vivo measurements
Georg Meisl, Alexander J Dear, Thomas CT Michaels +1
The formation and proliferation of protein aggregates play a central role in a number of devastating neuro-degenerative diseases. Many experimental studies indicate that the abilit…
A general reaction network unifies the aggregation behaviour of the A42 peptide and its variants
Georg Meisl, Xiaoting Yang, Christopher M. Dobson +2
The amyloid peptide (A42), whose aggregation is associated with Alzheimer's disease, is an amphiphatic peptide with a high propensity to self-assemble. A42 has a net nega…