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physics.bio-ph2026
Spatially Resolved Nucleated Polymerization: A Free-Boundary Model of Protein Aggregation in Concentrated Solutions
Pouria A. Mistani
Kinetic models of protein aggregation describe populations by size, not by spatial organization or morphology. We extend Lumry-Eyring nucleated polymerization to a model in which t…
physics.bio-ph2024★ 3 cited
Preference optimization of protein language models as a multi-objective binder design paradigm
Pouria Mistani, Venkatesh Mysore
We present a multi-objective binder design paradigm based on instruction fine-tuning and direct preference optimization (DPO) of autoregressive protein language models (pLMs). Mult…