88 citations · 187 across the 8 of their papers we have counts for
8 papers
Spatially Resolved Nucleated Polymerization: A Free-Boundary Model of Protein Aggregation in Concentrated Solutions
Pouria A. Mistani
Kinetic models of protein aggregation describe populations by size, not by spatial organization or morphology. We extend Lumry-Eyring nucleated polymerization to a model in which t…
Preference optimization of protein language models as a multi-objective binder design paradigm
Pouria Mistani, Venkatesh Mysore
We present a multi-objective binder design paradigm based on instruction fine-tuning and direct preference optimization (DPO) of autoregressive protein language models (pLMs). Mult…
Neuro-symbolic partial differential equation solver
Pouria Mistani, Samira Pakravan, Rajesh Ilango +2
We present a highly scalable strategy for developing mesh-free neuro-symbolic partial differential equation solvers from existing numerical discretizations found in scientific comp…
JAX-DIPS: Neural bootstrapping of finite discretization methods and application to elliptic problems with discontinuities
Pouria Mistani, Samira Pakravan, Rajesh Ilango +1
We present a scalable strategy for development of mesh-free hybrid neuro-symbolic partial differential equation solvers based on existing mesh-based numerical discretization method…
A fractional stochastic theory for interfacial polarization of cell aggregates
Pouria A. Mistani, Samira Pakravan, Frederic G. Gibou
We present a theoretical framework to model the electric response of cell aggregates. We establish a coarse representation for each cell as a combination of membrane and cytoplasm…
Solving inverse-PDE problems with physics-aware neural networks
Samira Pakravan, Pouria A. Mistani, Miguel Angel Aragon-Calvo +1
We propose a novel composite framework to find unknown fields in the context of inverse problems for partial differential equations (PDEs). We blend the high expressibility of deep…
A parallel Voronoi-based approach for mesoscale simulations of cell aggregate electropermeabilization
Pouria Mistani, Arthur Guittet, Clair Poignard +1
We introduce a numerical framework that enables unprecedented direct numerical studies of the electropermeabilization effects of a cell aggregate at the meso-scale. Our simulations…
On the Assembly of Dwarf Galaxies in Clusters and their Efficient Formation of Globular Clusters
Pouria A. Mistani, Laura V. Sales, Annalisa Pillepich +6
Galaxy clusters contain a large population of low mass dwarf elliptical galaxies whose exact origin is unclear: their colors, structural properties and kinematics differ substantia…