287 citations · 3.4k across the 49 of their papers we have counts for
6 papers · 1 filter
A general approximation for the dynamics of quantitative traits
Katarína Boďová, Gašper Tkačik, Nicholas H. Barton
Selection, mutation and random drift affect the dynamics of allele frequencies and consequently of quantitative traits. While the macroscopic dynamics of quantitative traits can be…
Extending the dynamic range of transcription factor action by translational regulation
Thomas R. Sokolowski, Aleksandra M. Walczak, William Bialek +1
A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar c…
Intrinsic limits to gene regulation by global crosstalk
Tamar Friedlander, Roshan Prizak, Călin C. Guet +2
Gene regulation relies on the specificity of transcription factor (TF) - DNA interactions. In equilibrium, limited specificity may lead to crosstalk: a regulatory state in which a…
Dynamics of transcription factor binding site evolution
Murat Tuğrul, Tiago Paixão, Nicholas H. Barton +1
Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription…
Stochastic proofreading mechanism alleviates crosstalk in transcriptional regulation
Sarah A Cepeda-Humerez, Georg Rieckh, Gašper Tkačik
Gene expression is controlled primarily by interactions between transcription factor proteins (TFs) and the regulatory DNA sequence, a process that can be captured well by thermody…
Optimizing information flow in small genetic networks. IV. Spatial coupling
Thomas R. Sokolowski, Gašper Tkačik
We typically think of cells as responding to external signals independently by regulating their gene expression levels, yet they often locally exchange information and coordinate.…