14 citations · 15 across the 4 of their papers we have counts for
4 papers
Adjusting for time-varying treatment switches in randomized clinical trials: the danger of extrapolation and how to avoid it
Hege Michiels, An Vandebosch, Stijn Vansteelandt
When choosing estimands and estimators in randomized clinical trials, caution is warranted as intercurrent events, such as - due to patients who switch treatment after disease prog…
A novel estimand to adjust for rescue treatment in clinical trials
Hege Michiels, Cristina Sotto, An Vandebosch +1
The interpretation of randomised clinical trial results is often complicated by intercurrent events. For instance, rescue medication is sometimes given to patients in response to w…
Efficient, Doubly Robust Estimation of the Effect of Dose Switching for Switchers in a Randomised Clinical Trial
Kelly Van Lancker, An Vandebosch, Stijn Vansteelandt
Motivated by a clinical trial conducted by Janssen Pharmaceuticals in which a flexible dosing regimen is compared to placebo, we evaluate how switchers in the treatment arm (i.e.,…
Improving interim decisions in randomized trials by exploiting information on short-term outcomes and prognostic baseline covariates
Kelly Van Lancker, An Vandebosch, Stijn Vansteelandt
Conditional power calculations are frequently used to guide the decision whether or not to stop a trial for futility or to modify planned sample size. These ignore the information…