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6 papers

physics.optics2026

Ultraviolet direct absorption microscopy for single particle protein/nucleic acid quantification

C. J. Richards, D. van de Lockand, D. Wolters +1

The paper introduces ultraviolet direct absorption microscopy (UV‑DAM), a label‑free imaging technique that uses deep‑UV illumination to measure protein and nucleic acid content of…

physics.optics2026

Motion-Based Beamshape Recovery Enables Precision Nanoparticle Sizing

D-Dré K. J. M. J. Braam, Daan Wolters, Matz Liebel

The paper presents a self‑normalising technique that reconstructs the illumination profile from the scattering signals of many freely diffusing nanoparticles, enabling precise, lab…

physics.optics2026

Bidirectional phase sensitivity in holographic phototransient microscopy

Emmanuel Kotu Robertson, Dennis van de Lockand, Matz Liebel

Mid-infrared photothermal microscopy combines the chemical specificity of infrared absorption with the spatial resolution of visible-light detection, but practical implementations…

physics.optics2026

Sub-Nyquist time-domain surface-enhanced Raman mapping

Ting Wang, I. Brian Becerril-Castro, Ana Sousa-Castillo +3

Surface-enhanced Raman scattering (SERS) combines analyte-specificity and single-molecule sensitivity, but its potential is limited by slow readout where sophisticated nanosensors…

physics.optics2025

The next dimension: Digital holography for 3D interferometric scattering

Jaime Ortega Arroyo, Matz Liebel

We provide detailed experimental guidelines for implementing digital holography in the context of high-sensitivity interferometric scattering (iSCAT) based nanosizing applications.…

physics.optics2025

Time-resolved infrared photothermal imaging: From transient observations towards the steady-state

Dennis van de Lockand, Daan Wolters, Matz Liebel

Mid-infrared photothermal microscopy is a highly promising imaging technique that enables spatially resolved vibrational fingerprinting. The combination of infrared induced heating…