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q-bio.CB2018
Confirmation that T cell receptor activation is digital, not analog. Hence individual T cell cytolytic capacity is independent of initial stimulation strength
Donald R. Forsdyke
Whether a sub-optimum lymphocyte stimulus is achieved by lowering ligand concentration, or decreasing its affinity, initial TCR activation responses are likely to be digital. We no…
q-bio.CB2018
Shift in Nomenclature not Thesis: Innate Immune Memory, Pathogen Dose and Opsonins
Donald R. Forsdyke
Recent writings on "innate immune memory" or "trained immunity," and on "hormetic responses," herald reinvigoration of an important research area with early 20th century roots. How…