7 citations · 22 across the 17 of their papers we have counts for
12 papers · 1 filter
Evaluation of histological findings with severity grade, to analyze toxicology in-vivo studies
Ludwig A. Hothorn, Klaus Weber
In-vivo toxicological studies are characterized by multiple primary endpoints with quite different scales. Whereas guidelines and publications provide various statistical tests for…
Closed testing procedures for treatment-versus-control comparisons and multiple correlated endpoint
Ludwig A. Hothorn, Siegfried Kropf
Preferably in two- or three-arm randomized clinical trials, a few (2,3) correlated multiple primary endpoints are considered. In addition to the closed testing principle based on d…
A statistical method for estimating the no-observed-adverse-event-level
Ludwig A. Hothorn
In toxicological risk assessment the benchmark dose (BMD) is recommended instead of the no-observed-adverse effect-level (NOAEL). Still a simple test procedure to estimate NOAEL is…
Closed test procedures for the comparison of dose groups against a negative control group or placebo
Ludwig A. Hothorn
Dose groups are compared with a control assuming an order restriction usually by the Williams trend test. Here, as an alternative, two variants of the closed testing procedure are…
Comparisons of multiple treatment groups with a negative control or placebo group: Dunnett test vs. closed test procedur
Ludwig A. Hothorn
Several treatments are usually compared with a control using the Dunnett test. As an alternative, three variants of the closed testing approach are considered, one with ANOVA-F-tes…
Comparisons of proportions in k dose groups against a negative control assuming order restriction: Williams-type test vs. closed test procedures
Ludwig A. Hothorn
The comparison of proportions is considered in the asymptotic generalized linear model with the odds ratio as effect size. When several doses are compared with a control assuming a…