7 citations · 22 across the 17 of their papers we have counts for
17 papers
Seven recommendations for alternatives to the common analysis of variance (ANOVA) with application in the life sciences -- using R
Ludwig A. Hothorn
Standard ANOVA is among the most widely used tests in the life sciences and beyond. Several alternatives are proposed to provide simultaneous confidence intervals, ensure tight con…
Simultaneous confidence intervals for the interpretation of primary and secondary effects in factorial designs without a pre-test on interaction
Ludwig A. Hothorn
The analysis of low dimensional factorial designs with possible interactions is a relevant issue. Instead of the common pre-tests for interaction, a simultaneous inference procedur…
Evaluation of histological findings with severity grade, to analyze toxicology in-vivo studies
Ludwig A. Hothorn, Klaus Weber
In-vivo toxicological studies are characterized by multiple primary endpoints with quite different scales. Whereas guidelines and publications provide various statistical tests for…
Closed testing procedures for treatment-versus-control comparisons and multiple correlated endpoint
Ludwig A. Hothorn, Siegfried Kropf
Preferably in two- or three-arm randomized clinical trials, a few (2,3) correlated multiple primary endpoints are considered. In addition to the closed testing principle based on d…
Simultaneous comparisons of treatments versus control (Dunnett-type tests) for location-scale alternatives
Ludwig A. Hothorn
Commonly, the comparisons of treatment groups versus a control is performed for location effects only where possible scale effects are considered as disturbing. Sometimes scale eff…
A statistical method for estimating the no-observed-adverse-event-level
Ludwig A. Hothorn
In toxicological risk assessment the benchmark dose (BMD) is recommended instead of the no-observed-adverse effect-level (NOAEL). Still a simple test procedure to estimate NOAEL is…