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stat.ME2022
Unbiased and Efficient Estimation of Causal Treatment Effects in Cross-over Trials
Jeppe Ekstrand Halkjær Madsen, Thomas Scheike, Christian Pipper
We introduce causal inference reasoning to cross-over trials, with a focus on Thorough QT (TQT) studies. For such trials, we propose different sets of assumptions and consider thei…
stat.ME2022
Properties of a confirmatory two-stage adaptive procedure for assessing average bioequivalence
Marie Louise Østerdal, Kyle Raymond, Christian Pipper
We investigate a confirmatory two stage adaptive procedure for assessing average bioequivalence and provide some insights to its theoretical properties. Effectively, we perform Two…