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An introduction to the mathematical modelling of iPSCs
Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova +3
The aim of this chapter is to convey the importance and usefulness of mathematical modelling as a tool to achieve a deeper understanding of stem cell biology. We introduce key math…
OCT4 expression in human embryonic stem cells: spatio-temporal dynamics and fate transitions
Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova +5
The improved in-vitro regulation of human embryonic stem cell (hESC) pluripotency and differentiation trajectories is required for their promising clinical applications. The tempor…
SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways
Waradon Sungnak, Ni Huang, Christophe Bécavin +2
The SARS-CoV-2 coronavirus, the etiologic agent responsible for COVID-19 coronavirus disease, is a global threat. To better understand viral tropism, we assessed the RNA expression…
The recent advances in the mathematical modelling of human pluripotent stem cells
L E Wadkin, S Orozco-Fuentes, I Neganova +3
Human pluripotent stem cells hold great promise for developments in regenerative medicine and drug design. The mathematical modelling of stem cells and their properties is necessar…
Correlated random walks of human embryonic stem cell in-vitro
L E Wadkin, S Orozco-Fuentes, I Neganova +5
We perform a detailed analysis of the migratory motion of human embryonic stem cells in two-dimensions, both when isolated and in close proximity to another cell, recorded with tim…