2.7k citations · 2.8k across the 7 of their papers we have counts for
8 papers
A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells
L E Wadkin, S Orozco-Fuentes, I Neganova +3
Human pluripotent stem cells (hPSCs) have promising clinical applications in regenerative medicine, drug-discovery and personalised medicine due to their potential to differentiate…
An introduction to the mathematical modelling of iPSCs
Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova +3
The aim of this chapter is to convey the importance and usefulness of mathematical modelling as a tool to achieve a deeper understanding of stem cell biology. We introduce key math…
OCT4 expression in human embryonic stem cells: spatio-temporal dynamics and fate transitions
Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova +5
The improved in-vitro regulation of human embryonic stem cell (hESC) pluripotency and differentiation trajectories is required for their promising clinical applications. The tempor…
SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways
Waradon Sungnak, Ni Huang, Christophe Bécavin +2
The SARS-CoV-2 coronavirus, the etiologic agent responsible for COVID-19 coronavirus disease, is a global threat. To better understand viral tropism, we assessed the RNA expression…
The recent advances in the mathematical modelling of human pluripotent stem cells
L E Wadkin, S Orozco-Fuentes, I Neganova +3
Human pluripotent stem cells hold great promise for developments in regenerative medicine and drug design. The mathematical modelling of stem cells and their properties is necessar…
Quantification of the morphological characteristics of hESC colonies
Sirio Orozco-Fuentes, Irina Neganova, Laura E. Wadkin +5
The maintenance of the pluripotent state in human embryonic stem cells (hESCs) is critical for further application in regenerative medicine, drug testing and studies of fundamental…