661 citations · 1.1k across the 7 of their papers we have counts for
7 papers
Designability and Thermal Stability of Protein Structures
Ned Wingreen, Hao Li, Chao Tang
Only about 1,000 qualitatively different protein folds are believed to exist in nature. Here, we review theoretical studies which suggest that some folds are intrinsically more des…
The Designability of Protein Structures: A Lattice-Model Study using the Miyazawa-Jernigan Matrix
Hao Li, Chao Tang, Ned Wingreen
We study the designability of all compact 3x3x3 and 6x6 lattice-protein structures using the Miyazawa-Jernigan (MJ) matrix. The designability of a structure is the number of sequen…
Fast Tree Search for Enumeration of a Lattice Model of Protein Folding
Henry Cejtin, Jan Edler, Allan Gottlieb +5
Using a fast tree-searching algorithm and a Pentium cluster, we enumerated all the sequences and compact conformations (structures) for a protein folding model on a cubic lattice o…
Designability, thermodynamic stability, and dynamics in protein folding: a lattice model study
Régis Mélin, Hao Li, Ned S. Wingreen +1
In the framework of a lattice-model study of protein folding, we investigate the interplay between designability, thermodynamic stability, and kinetics. To be ``protein-like'', het…
Are Protein Folds Atypical?
Hao Li, Chao Tang, Ned S. Wingreen
Protein structures are a very special class among all possible structures. It was suggested that a ``designability principle'' plays a crucial role in nature's selection of protein…
Why Do Proteins Look Like Proteins?
Hao Li, Robert Helling, Chao Tang +1
Protein structures in nature often exhibit a high degree of regularity (secondary structures, tertiary symmetries, etc.) absent in random compact conformations. We demonstrate in a…
Nature of Driving Force for Protein Folding -- A Result From Analyzing the Statistical Potential
Hao Li, Chao Tang, Ned Wingreen
In a statistical approach to protein structure analysis, Miyazawa and Jernigan (MJ) derived a matrix of inter-residue contact energies between different types of amin…