195 citations · 399 across the 8 of their papers we have counts for
3 papers · 1 filter
Using phase II data for the analysis of phase III studies: an application in rare diseases
Simon Wandel, Beat Neuenschwander, Tim Friede +1
Clinical research and drug development in orphan diseases is challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is there…
Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases
Tim Friede, Christian Röver, Simon Wandel +1
Random-effects meta-analyses are used to combine evidence of treatment effects from multiple studies. Since treatment effects may vary across trials due to differences in study cha…
Meta-analysis of few small studies in orphan diseases
Tim Friede, Christian Röver, Simon Wandel +1
Meta-analyses in orphan diseases and small populations generally face particular problems including small numbers of studies, small study sizes, and heterogeneity of results. Howev…