204 citations · 1.3k across the 41 of their papers we have counts for
9 papers · 1 filter
Identification of microRNA clusters cooperatively acting on Epithelial to Mesenchymal Transition in Triple Negative Breast Cancer
Laura Cantini, Gloria Bertoli, Claudia Cava +6
MicroRNAs play important roles in many biological processes. Their aberrant expression can have oncogenic or tumor suppressor function directly participating to carcinogenesis, mal…
Predicting genetic interactions from Boolean models of biological networks
Laurence Calzone, Emmanuel Barillot, Andrei Zinovyev
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.…
Model composition through model reduction: a combined model of CD95 and NF-κB signaling pathways
Elena Kutumova, Andrei Zinovyev, Ruslan Sharipov +1
We propose a new approach to model composition, based on reducing several models to the same level of complexity and subsequent combining them together. Firstly, we suggest a set o…
NaviCell: a web-based environment for navigation, curation and maintenance of large molecular interaction maps
Inna Kuperstein, David PA Cohen, Stuart Pook +3
Molecular biology knowledge can be systematically represented in a computer-readable form as a comprehensive map of molecular interactions. There exist a number of maps of molecula…
Cell death and life in cancer: mathematical modeling of cell fate decisions
Andrei Zinovyev, Simon Fourquet, Laurent Tournier +2
Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells. Understanding this process…
Reduction of dynamical biochemical reaction networks in computational biology
Ovidiu Radulescu, Alexander N. Gorban, Andrei Zinovyev +1
Biochemical networks are used in computational biology, to model the static and dynamical details of systems involved in cell signaling, metabolism, and regulation of gene expressi…