184 citations · 704 across the 38 of their papers we have counts for
8 papers · 1 filter
Topological classification of tumour-immune interactions and dynamics
Jingjie Yang, Heidi Fang, Jagdeep Dhesi +5
The complex and dynamic crosstalk between tumour and immune cells results in tumours that can exhibit distinct qualitative behaviours - elimination, equilibrium, and escape - and i…
A new lipid-structured model to investigate the opposing effects of LDL and HDL on atherosclerotic plaque macrophages
Keith L Chambers, Mary R Myerscough, Helen M Byrne
Atherosclerotic plaques form in artery walls due to a chronic inflammatory response driven by lipid accumulation. A key component of the inflammatory response is the interaction be…
Macrophage anti-inflammatory behaviour in a multiphase model of atherosclerotic plaque development
Ishraq U. Ahmed, Helen M. Byrne, Mary R. Myerscough
Atherosclerosis is an inflammatory disease characterised by the formation of plaques, which are deposits of lipids and cholesterol-laden macrophages that form in the artery wall. T…
Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration
W. Duncan Martinson, Rebecca McLennan, Jessica M. Teddy +6
Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclea…
Spatio-temporal modelling of phenotypic heterogeneity in tumour tissues and its impact on radiotherapy treatment
Giulia L. Celora, Helen M. Byrne, P. G. Kevrekidis
We present a mathematical model that describes how tumour heterogeneity evolves in a tissue slice that is oxygenated by a single blood vessel. Phenotype is identified with the stem…
Phenotypic variation modulates the growth dynamics and response to radiotherapy of solid tumours under normoxia and hypoxia
Giulia L. Celora, Helen M. Byrne, Christos Zois +1
In cancer, treatment failure and disease recurrence have been associated with small subpopulations of cancer cells with a stem-like phenotype. In this paper, we develop and investi…
A Multiphase Model of Growth Factor-Regulated Atherosclerotic Cap Formation
Michael G. Watson, Helen M. Byrne, Charlie Macaskill +1
Atherosclerosis is characterised by the growth of fatty plaques in the inner (intimal) layer of the artery wall. In mature plaques, vascular smooth muscle cells (SMCs) are recruite…
A Two-Phase Model of Early Fibrous Cap Formation in Atherosclerosis
Michael G. Watson, Helen M. Byrne, Charlie Macaskill +1
Atherosclerotic plaque growth is characterised by chronic inflammation that promotes accumulation of cellular debris and extracellular fat in the inner artery wall. This material i…