11 papers
Trustworthy Protein-Ligand Binding Affinity Prediction via Reliability-Aware Multi-Engine Fusion
Yongchan Hong, Defu Cao, Wenjin Liu +6
Accurate protein-ligand binding affinity prediction is central to computational drug discovery, yet modern docking engines frequently disagree without indicating which prediction t…
Speaking Numbers to LLMs: Multi-Wavelet Number Embeddings for Time Series Forecasting
Defu Cao, Zijie Lei, Muyan Weng +2
Large language models (LLMs) are attractive for context-aware time series forecasting because they can integrate heterogeneous textual signals, yet their discrete, language-oriente…
A Survey of Reasoning and Agentic Systems in Time Series with Large Language Models
Ching Chang, Yidan Shi, Defu Cao +8
Time series reasoning treats time as a first-class axis and incorporates intermediate evidence directly into the answer. This survey defines the problem and organizes the literatur…
PG-LRF: Physiology-Guided Latent Rectified Flow for Electro-Hemodynamic PPG-to-ECG Generation
Xiaoda Wang, Minxiao Wang, Kaiqiao Han +10
Electrocardiography (ECG) is the clinical standard for cardiac assessment but requires dedicated hardware that does not scale to daily-life monitoring. Photoplethysmography (PPG) i…
TS-Reasoner: Domain-Oriented Time Series Inference Agents for Reasoning and Automated Analysis
Wen Ye, Wei Yang, Defu Cao +4
Time series analysis is crucial in real-world applications, yet traditional methods focus on isolated tasks only, and recent studies on time series reasoning remain limited to eith…
Adaptive Collaboration with Humans: Metacognitive Policy Optimization for Multi-Agent LLMs with Continual Learning
Wei Yang, Defu Cao, Jiacheng Pang +2
While scaling individual Large Language Models (LLMs) has delivered remarkable progress, the next frontier lies in scaling collaboration through multi-agent systems (MAS). However,…