5 papers
Thermal denaturation and folding rates of single domain proteins: size matters
Mai Suan Li, D. K. Klimov, D. Thirumalai
We analyze the dependence of thermal denaturation transition and folding rates of globular proteins on the number of amino acid residues, N. Using lattice Go models we show that De…
Dependence of folding rates on protein length
Mai Suan Li, D. K. Klimov, D. Thirumalai
Using three-dimensional Go lattice models with side chains for proteins, we investigate the dependence of folding times on protein length. In agreement with previous theoretical pr…
Introducing Protein Folding Using Simple Models
D. Thirumalai, D. K. Klimov
We discuss recent theoretical developments in the study of simple lattice models of proteins. Such models are designed to understand general features of protein structures and mech…
Cooperativity in Protein Folding: From Lattice Models with Side Chains to Real Proteins
D. K. Klimov, D. Thirumalai
We consider equilibrium folding transitions in lattice protein models with and without side chains. A dimensionless measure, , is introduced to quantitatively assess the…
Factors Governing the Foldability of Proteins
D. K. Klimov, D. Thirumalai
We use a three dimensional cubic lattice model of proteins to study their properties that determine folding to the native state. The protein chain is modeled as a sequence of b…