16 citations · 72 across the 18 of their papers we have counts for
7 papers · 1 filter
On Bayesian Sequential Clinical Trial Designs
Tianjian Zhou, Yuan Ji
Clinical trials usually involve sequential patient entry. When designing a clinical trial, it is often desirable to include a provision for interim analyses of accumulating data wi…
A Unified Decision Framework for Phase I Dose-Finding Designs
Yunshan Duan, Shijie Yuan, Yuan Ji +1
The purpose of a phase I dose-finding clinical trial is to investigate the toxicity profiles of various doses for a new drug and identify the maximum tolerated dose. Over the past…
Incorporating External Data into the Analysis of Clinical Trials via Bayesian Additive Regression Trees
Tianjian Zhou, Yuan Ji
Most clinical trials involve the comparison of a new treatment to a control arm (e.g., the standard of care) and the estimation of a treatment effect. External data, including hist…
BaySize: Bayesian Sample Size Planning for Phase I Dose-Finding Trials
Xiaolei Lin, Jiaying Lyu, Shijie Yuan +2
We propose BaySize, a sample size calculator for phase I clinical trials using Bayesian models. BaySize applies the concept of effect size in dose finding, assuming the MTD is defi…
PoD-BIN: A Probability of Decision Bayesian Interval Design for Time-to-Event Dose-Finding Trials with Multiple Toxicity Grades
Meizi Liu, Yuan Ji, Ji Lin
We consider a Bayesian framework based on "probability of decision" for dose-finding trial designs. The proposed PoD-BIN design evaluates the posterior predictive probabilities of…
The Ci3+3 Design for Dual-Agent Combination Dose-Finding Clinical Trials
Shijie Yuan, Tianjian Zhou, Yawen Lin +1
We propose a rule-based statistical design for combination dose-finding trials with two agents. The Ci3+3 design is an extension of the i3+3 design with simple decision rules compa…
Lessons Learned from the Bayesian Design and Analysis for the BNT162b2 COVID-19 Vaccine Phase 3 Trial
Yuan Ji, Shijie Yuan
The phase III BNT162b2 mRNA COVID-19 vaccine trial is based on a Bayesian design and analysis, and the main evidence of vaccine efficacy is presented in Bayesian statistics. Confus…