402 citations · 8.7k across the 191 of their papers we have counts for
32 papers · 1 filter
Nucleoid clustering drives stepwise expansion and segregation of replicating bacterial chromosomes
Giada Forte, Enzo Orlandini, Davide Marenduzzo
Bacterial chromosome replication occurs in the absence of a canonical spindle apparatus; yet it reliably produces organised and segregated genomes. While both passive and active me…
Modelling transcriptional silencing and its coupling to 3D genome organisation
Massimiliano Semeraro, Giuseppe Negro, Davide Marenduzzo +1
Timely up- or down-regulation of gene expression is crucial for cellular differentiation and function. While gene upregulation via transcriptional activators has been extensively i…
Topological weight and structural diversity of polydisperse chromatin loop networks
Andrea Bonato, Enrico Carlon, Sergey Kitaev +2
Current biophysical models for transcriptionally active chromatin view this as a polymer with sticky sites, mimicking transcription units such as promoters and enhancers which inte…
Oscillation in the SIRS model
D. Marenduzzo, A. T. Brown, C. Miller +1
We study the SIRS epidemic model, both analytically and on a square lattice. The analytic model has two stable solutions, post outbreak/epidemic (no infected, ) and the endemi…
Bridging-Induced Phase Separation and Loop Extrusion Drive Noise in Chromatin Transcription
Michael Chiang, Cleis Battaglia, Giada Forte +3
Transcriptional noise, or heterogeneity, is important in cellular development and in disease. The molecular mechanisms driving it are, however, elusive and ill-understood. Here, we…
Topological spectra and entropy of chromatin loop networks
Andrea Bonato, Dom Corbett, Sergey Kitaev +3
The 3D folding of a mammalian gene can be studied by a polymer model, where the chromatin fibre is represented by a semiflexible polymer which interacts with multivalent proteins,…