4 papers
PertReason: A Knowledge-Grounded Benchmark and Framework for Cell-State-Conditioned Mechanistic Reasoning of Perturbation Effects
Dongkwan Kim, Yiming Gao, Yining Yang +1
Evaluating machine learning in scientific domains requires separating correct predictions from correct reasons under realistic distribution shifts. We introduce PertReason, a knowl…
Multi-Task Genetic Algorithm with Multi-Granularity Encoding for Protein-Nucleotide Binding Site Prediction
Yiming Gao, Liuyi Xu, Pengshan Cui +3
Accurate identification of protein-nucleotide binding sites is fundamental to deciphering molecular mechanisms and accelerating drug discovery. However, current computational metho…
CellMaster: Collaborative Cell Type Annotation in Single-Cell Analysis
Zhen Wang, Yiming Gao, Jieyuan Liu +10
Single-cell RNA-seq (scRNA-seq) enables atlas-scale profiling of complex tissues, revealing rare lineages and transient states. Yet, assigning biologically valid cell identities re…
scPilot: Large Language Model Reasoning Toward Automated Single-Cell Analysis and Discovery
Yiming Gao, Zhen Wang, Jefferson Chen +8
We present scPilot, the first systematic framework to practice omics-native reasoning: a large language model (LLM) converses in natural language while directly inspecting single-c…