96 citations · 118 across the 6 of their papers we have counts for
7 papers
Mathematical modelling of immune persistence and relapse pathways in CAR T-cell therapy for B-ALL
Alexis Farman, Benjamin J. Walker, Martin A. Pule +1
Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of B-cell acute lymphoblastic leukaemia (B-ALL). Despite high initial response rates, a substantial fra…
An agent-based modelling framework to study growth mechanisms in EGFR-L858R mutant alveolar type II cells
Helena Coggan, Clare E. Weeden, Philip Pearce +4
Mutations in the epidermal growth factor receptor (EGFR) are common in non-small cell lung cancer (NSCLC), particularly in never-smoker patients. However, these mutations are not a…
Evolution of cooperation on an epithelium
Jessie Renton, Karen M. Page
Cooperation is prevalent in nature, not only in the context of social interactions within the animal kingdom, but also on the cellular level. In cancer for example, tumour cells ca…
Degradation rate uniformity determines success of oscillations in repressive feedback regulatory networks
Karen M. Page, Ruben Perez-Carrasco
Ring oscillators are biochemical circuits consisting of a ring of interactions capable of sustained oscillations. The non-linear interactions between genes hinder the analytical in…
The power of the AC-DC circuit: Operating principles of a simple multi-functional transcriptional network motif
Ruben Perez-Carrasco, Chris P. Barnes, Yolanda Schaerli +3
Genetically encoded regulatory circuits control biological function. A major focus of systems biology is to understand these circuits by establishing the relationship between speci…
Minimum Action Path theory reveals the details of stochastic biochemical transitions out of oscillatory cellular states
Roberto de la Cruz, Ruben Perez-Carrasco, Pilar Guerrero +2
Cell state determination is the outcome of intrinsically stochastic biochemical reactions. Tran- sitions between such states are studied as noise-driven escape problems in the chem…