Bistability of cell-matrix adhesions resulting from non-linear receptor-ligand dynamics

Abstract

Bistability is a major mechanism for cellular decision making and usually results from positive feedback in biochemical control systems. Here we show theoretically that bistability between unbound and bound states of adhesion clusters results from positive feedback mediated by structural rather than biochemical processes, namely by receptor-ligand dissociation and association dynamics which depend non-linearly on mechanical force and receptor-ligand separation. For small cell-matrix adhesions, we find rapid switching between unbound and bound states, which in the initial stages of adhesion allows the cell to explore its environment through many transient adhesions.

Revtex, 3 pages, 3 postscript figures included, to appear in Biophysical Journal as Biophysical Letter

References in corpus (1)

• Stability of adhesion clusters under constant force

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