Stochastic dynamics of adhesion clusters under shared constant force and with rebinding
arXiv:cond-mat/0405247 · doi:10.1063/1.1805496
Abstract
Single receptor-ligand bonds have finite lifetimes, so that biological systems can dynamically react to changes in their environment. In cell adhesion, adhesion bonds usually act cooperatively in adhesion clusters. Outside the cellular context, adhesion clusters can be probed quantitatively by attaching receptors and ligands to opposing surfaces. Here we present a detailed theoretical analysis of the stochastic dynamics of a cluster of parallel bonds under shared constant loading and with rebinding. Analytical solutions for the appropriate one-step master equation are presented for special cases, while the general case is treated with exact stochastic simulations. If the completely dissociated state is modeled as an absorbing boundary, mean cluster lifetime is finite and can be calculated exactly. We also present a detailed analysis of fluctuation effects and discuss various approximations to the full stochastic description.
Revtex, 29 pages, 23 postscript figures included (some with reduced image quality)
References in corpus (5)
- Rupture of multiple parallel molecular bonds under dynamic loading
- Stability of adhesion clusters under constant force
- Adhesion clusters under shared linear loading: a stochastic analysis
- L-selectin mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events
- Escape from a metastable well under a time-ramped force
Cited by in corpus (17)
- Physics of adherent cells
- Impact of receptor-ligand distance on adhesion cluster stability
- Physics of muscle contraction
- Stochastic dynamics of small ensembles of non-processive molecular motors: the parallel cluster model
- Stochastic simulations of cargo transport by processive molecular motors
- Focal adhesion kinase - the reversible molecular mechanosensor
- Paramagnetic response of muscle-type systems
- Statistical mechanics of the Huxley-Simmons model
- Mechanical and Systems Biology of Cancer
- Dynamic force spectroscopy on multiple bonds: experiments and model
- Criticality in Cell Adhesion
- Forced desorption of semiflexible polymers, adsorbed and driven by molecular motors
- Cooperative crosslink (un)binding in slowly driven bundles of semiflexible filaments
- Stability of heterogeneous parallel-bond adhesion clusters under static load
- Active gel model for one-dimensional cell migration coupling actin flow and adhesion dynamics
- First-passage times in complex energy landscapes: a case study with nonmuscle myosin II assembly
- Fluctuations in first passage times and utility of resetting protocol in biochemical systems with two-state toggling