Detachment of molecular motors under tangential loading

Abstract

We introduce a general framework to study the processivity of molecular motors moving along a polar filament and discuss the average time spent attached to the filament as a function of a tangentially applied load. Our study of specific models suggests that the attachment time of a motor decreases with increasing ATP concentration and that double-headed motors such as kinesins lose their processivity under forcing conditions while processive single-headed motors are less sensitive to tangential forcing.

7 pages, 5 figures. To be published on Europhysics Letters

Cited by in corpus (13)

• Cytoplasmic Streaming in Plant Cells Emerges Naturally by Microfilament Self-Organization
• Understanding Mechanochemical Coupling in Kinesins Using First-Passage Time Processes
• Mechanical response of active gels
• Internal Motility in Stiffening Actin-Myosin Networks
• Dynamics of Molecular Motors with Finite Processivity on Heterogeneous Tracks
• Velocity and processivity of helicase unwinding of double-stranded nucleic acids
• Sequence heterogeneity and the dynamics of molecular motors
• Renewal processes and fluctuation analysis of molecular motor stepping
• Memory, Bias and Correlations in Bidirectional Transport of Molecular Motor-driven Cargoes
• Motor-driven Dynamics of Cytoskeletal FIlaments in Motility Assays
• One Dimensional Exclusion Process with Dynein Inspired Hops: Simulation and Mean Field Analysis
• Effect of microtubule-associated protein tau in dynamics of single-headed motor proteins KIF1A
• Markov Process of Muscle Motors