Benchmarking of Fluorescence Lifetime Measurements using Time-Frequency Correlated Photons
arXiv:2501.08870 · doi:10.1515/mim-2025-0001
Abstract
The investigation of fluorescence lifetime became an important tool in biology and medical science. So far, established methods of fluorescence lifetime measurements require the illumination of the investigated probes with pulsed or amplitude-modulated light. In this paper, we examine the limitations of an innovative method of fluorescence lifetime using the strong time-frequency correlation of entangled photons generated by a continuous-wave source. For this purpose, we investigate the lifetime of IR-140 to demonstrate the functional principle and its dependencies on different experimental parameters. We also compare this technique with state-of-the-art FLIM and observed an improved figure-of-merit. Finally, we discuss the potential of a quantum advantage.
12 pages, 13 figures
References in corpus (13)
- Experimental realization of sub-shot-noise quantum imaging
- A wavelength-tunable fiber-coupled source of narrowband entangled photons
- Mach-Zehnder Interferometry at the Heisenberg Limit with coherent and squeezed-vacuum light
- Spontaneous parametric down-conversion
- Quantum-enhanced absorption spectroscopy
- Highly efficient heralding of entangled single photons
- Temperature-Controlled Entangled-Photon Absorption Spectroscopy
- Ultrabright Polarization-Entangled Photon Pair Source for Frequency-Multiplexed Quantum Communication in Free-Space
- Entangled-Photon Coincidence Fluorescence Imaging
- Experimental realization of scanning quantum microscopy
- Integrated, bright, broadband parametric down-conversion source for quantum metrology and spectroscopy
- Photon Pair Source based on PPLN-Waveguides for Entangled Two-Photon Absorption
- Benchmarking of Fluorescence Lifetime Measurements using Time-Frequency Correlated Photons
Cited by in corpus (3)
- Benchmarking of Fluorescence Lifetime Measurements using Time-Frequency Correlated Photons
- Two-dimensional fluorescence spectroscopy with quantum entangled photons and time- and frequency-resolved two-photon coincidence detection
- Two-dimensional fluorescence spectroscopy with quantum entangled photons: Idler-referenced timing without pump detection