Chemotaxis-induced phase separation

Abstract

Chemotaxis allows single cells to self-organize at the population level, as classically described by Keller-Segel models. We show that chemotactic aggregation can be understood using a generalized Maxwell construction based on the balance of density fluxes and reactive turnover. This formulation implies that aggregates generically undergo coarsening, which is interrupted and reversed by cell growth and death. Together, both stable and spatiotemporally dynamic aggregates emerge. Our theory mechanistically links chemotactic self-organization to phase separation and reaction-diffusion patterns.

8 pages Main text, 25 pages Supplementary Information; 4 figures; v2: published version

References in corpus (26)

• SciPy 1.0--Fundamental Algorithms for Scientific Computing in Python
• Statistical Mechanics of Interacting Run-and-Tumble Bacteria
• A mass conserved reaction-diffusion system captures properties of cell polarity
• Stripe formation in bacterial systems with density-suppressed motility
• Generalized Thermodynamics of Phase Equilibria in Scalar Active Matter
• Cluster phases and bubbly phase separation in active fluids: Reversal of the Ostwald process
• Generalized thermodynamics of Motility-Induced Phase Separation: Phase equilibria, Laplace pressure, and change of ensembles
• Clustering and pattern formation in chemorepulsive active colloids
• Phase-space geometry of mass-conserving reaction-diffusion dynamics
• Mesa-type patterns in the one-dimensional Brusselator and their stability
• Capillary interfacial tension in active phase separation
• Mechanical Theory of Nonequilibrium Coexistence and Motility-Induced Phase Separation
• On the transient and steady state of mass-conserved reaction diffusion systems
• Enzyme-enriched condensates show self-propulsion, positioning, and coexistence
• Non-equilibrium phase separation with reactions: A canonical model and its behaviour
• Classical Nucleation Theory for Active Fluid Phase Separation
• Lamellar to micellar phases and beyond: when tactic active systems admit free-energy functionals
• Active Brownian agents with concentration-dependent chemotactic sensitivity
• Self-Replication of Mesa Patterns in Reaction-Diffusion Systems
• Self-consistent sharp interface theory of active condensate dynamics
• Coarsening and wavelength selection far from equilibrium: a unifying framework based on singular perturbation theory
• Theory of Capillary Tension and Interfacial Dynamics of Motility-Induced Phases
• Diffusive coupling of two well-mixed compartments elucidates elementary principles of protein-based pattern formation
• Fluctuating hydrodynamics of active particles interacting via taxis and quorum sensing: static and dynamics
• Anomalous Collective Dynamics of Auto-Chemotactic Populations
• Coarsening dynamics of chemotactic aggregates