Cellular Griffiths-like phase

Abstract

Protein compartmentalization in the frame of a liquid-liquid phase separation is a key mechanism to optimize spatiotemporal control of biological systems. Such a compartmentalization process reduces the intrinsic noise in protein concentration due to stochasticity in gene expression. Employing Flory-Huggins solution theory, Avramov/Casalini's model, and the Grüneisen parameter, we unprecedentedly propose a cellular Griffiths-like phase (CGLP), which can impact its functionality and self-organization. The here-proposed CGLP is key ranging from the understanding of primary organisms' evolution to the treatment of diseases. Our findings pave the way for an alternative Biophysics approach to investigate coacervation processes.

13 pages, 2 figures, suppl. material upon request

References in corpus (15)

• Griffiths phases and the stretching of criticality in brain networks
• Universally diverging Grueneisen parameter and the magnetocaloric effect close to quantum critical points
• Thermodynamical Scaling of the Glass Transition Dynamics
• Membraneless organelles formed by liquid-liquid phase separation increase bacterial fitness
• Concentration Dependence of the Flory Chi Parameter within Two-State Models
• Electronic Griffiths phase of the d=2 Mott transition
• Scaling theory of the Mott transition and breakdown of the Grüneisen scaling near a finite-temperature critical end point
• Phases and phase transitions in disordered quantum systems
• Griffiths phase and long-range correlations in a biologically motivated V1 model
• Griffiths-like phase close to the Mott transition
• Grüneisen Parameter for Gases
• Enhanced Grüneisen Parameter in Supercooled Water
• Grüneisen parameter as an entanglement compass and the breakdown of the Hellmann-Feynman theorem
• Unveiling the Physics of the Mutual Interactions in Paramagnets
• Phase separation in complex mixtures with many components: analytical expressions for spinodal manifolds