Improved test-retest reliability of ${\text{R}}_2^{\ast }$ and susceptibility quantification using multi-shot multi echo 3D EPI

Abstract

This study aimed to evaluate the potential of 3D echo-planar imaging (EPI) for improving the reliability of $T_2^{\ast }$-weighted ($T_2^{\ast }w$) data and quantification of ${\text{R}}_2^{\ast }$ decay rate and susceptibility ($\chi$) compared to conventional gradient echo (GRE)-based acquisition. Eight healthy subjects in a wide age range were recruited. Each subject received repeated scans for both GRE and EPI acquisitions with an isotropic 1 mm resolution at 3 T. Maps of ${\text{R}}_2^{\ast }$ and $\chi$ were quantified and compared using their inter-scan difference to evaluate the test-retest reliability. Inter-protocol differences of ${\text{R}}_2^{\ast }$ and $\chi$ between GRE and EPI were also measured voxel by voxel and in selected ROIs to test the consistency between the two acquisition methods. The quantifications of ${\text{R}}_2^{\ast }$ and $\chi$ using EPI protocols showed increased test-retest reliability with higher EPI factors up to 5 as performed in the experiment and were consistent with those based on GRE. This result suggested multi-shot multi-echo 3D EPI can be a useful alternative acquisition method for $T_2^{\ast }w$ MRI and quantification of ${\text{R}}_2^{\ast }$ and $\chi$ with reduced scan time, improved test-retest reliability and similar accuracy compared to commonly used 3D GRE.

18 pages, 8 figures and 1 table