Article Commentary on "Microdosimetric and radiobiological effects of gold nanoparticles at therapeutic radiation energies" [T.M. Gray et al., IJRB 2023, 99(2), 308-317]

Abstract

In the recently published article by T.M. Gray et al. "Microdosimetric and radiobiological effects of gold nanoparticles at therapeutic radiation energies" (IJRB 2023, 99(2), 308-317) results of Monte Carlo simulations and radiobiological assays on the dosimetric effects of gold nanoparticles were presented. This commentary points out that the results of the two parts of the study are in contradiction and that the predicted magnitude of dose enhancement and its dependence on the shape of the nanoparticle appear implausible. Possible reasons for these observations are discussed.

19 pages, 4 figures, 2 tables. Submitted to IJRB

References in corpus (2)

• Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: assessing the uncertainty and correct methodology for extended beams
• Consistency checks of results from a Monte Carlo code intercomparison for emitted electron spectra and energy deposition around a single gold nanoparticle irradiated by X-rays