Universal Transitions between Growth and Dormancy via Intermediate Complex Formation

Abstract

A simple cell model consisting of a catalytic reaction network with intermediate complex formation is numerically studied. As nutrients are depleted, the transition from the exponential growth phase to the growth-arrested dormant phase occurs along with hysteresis and a lag time for growth recovery. This transition is caused by the accumulation of intermediate complexes, leading to the jamming of reactions and the diversification of components. These properties are generic in random reaction networks, as supported by dynamical systems analyses of corresponding mean-field models.

arXiv comment6+6 pages, 3+6 figures

References in corpus (7)

• Zipf's Law in Gene Expression
• Fundamental Principles in Bacterial Physiology - History, Recent progress, and the Future with Focus on Cell Size Control: A Review
• Autocatalytic Sets and the Growth of Complexity in an Evolutionary Model
• Jamming, hysteresis and oscillation in scalar models for shear thickening
• Theory for transitions between log and stationary phases: universal laws for lag time
• Inverse Relationship Between Molecular Diversity And Resource Abundances
• Saddle-Node Bifurcation to Jammed State for Quasi-One-Dimensional Counter Chemotactic Flow