Controlling the spontaneous firing behavior of a neuron with astrocyte

Abstract

Mounting evidence in recent years suggests that astrocytes, a sub-type of glial cells, not only serve metabolic and structural support for neurons and synapses but also play critical roles in regulation of proper functioning of the nervous system. In this work, we investigate the effect of astrocyte on the spontaneous firing activity of a neuron through a combined model which includes a neuron-astrocyte pair. First, we show that an astrocyte may provide a kind of multistability in neuron dynamics by inducing different firing modes such as random and bursty spiking. Then, we identify the underlying mechanism of this behavior and search for the astrocytic factors that may have regulatory roles in different firing regimes. More specifically, we explore how an astrocyte can participate in occurrence and control of spontaneous irregular spiking activity of a neuron in random spiking mode. Additionally, we systematically investigate the bursty firing regime dynamics of the neuron under the variation of biophysical facts related to the intracellular environment of the astrocyte. It is found that an astrocyte coupled to a neuron can provide a control mechanism for both spontaneous firing irregularity and burst firing statistics, i.e., burst regularity and size.

arXiv comment11 pages, 11 figures; accepted for publication in Chaos: An Interdisciplinary Journal of Nonlinear Science, 2022

References in corpus (5)

• Stochastic resonance as a collective property of ion channel assemblies
• Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes
• Controlling the spontaneous spiking regularity via channel blocking on Newman-Watts networks of Hodgkin-Huxley neurons
• Homeostatic plasticity and external input shape neural network dynamics
• Collective dynamics of heterogeneously and nonlinearly coupled phase oscillators