Thermodynamics of Non-Elementary Chemical Reaction Networks

Abstract

We develop a thermodynamic framework for closed and open chemical networks applicable to non-elementary reactions that do not need to obey mass action kinetics. It only requires the knowledge of the kinetics and of the standard chemical potentials, and makes use of the topological properties of the network (conservation laws and cycles). Our approach is proven to be exact if the network results from a bigger network of elementary reactions where the fast-evolving species have been coarse grained. Our work should be particularly relevant for energetic considerations in biosystems where the characterization of the elementary dynamics is seldomly achieved.

References in corpus (3)

• Ensemble and Trajectory Thermodynamics: A Brief Introduction
• Irreversible thermodynamics of open chemical networks I: Emergent cycles and broken conservation laws
• The validity of quasi steady-state approximations in discrete stochastic simulations

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