Impact of intervention on the spread of COVID-19 in India: A model based study

Abstract

The outbreak of corona virus disease 2019 (COVID-19), caused by the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already created emergency situations in almost every country of the world. The disease spreads all over the world within a very short period of time after its first identification in Wuhan, China in December, 2019. In India, the outbreaks starts on $2^{nd}$ March, 2020 and after that the cases are increasing exponentially. Very high population density, the unavailability of specific medicines or vaccines, insufficient evidences regarding the transmission mechanism of the disease also make it difficult to fight against the disease properly in India. Mathematical models have been used to predict the disease dynamics and also to assess the efficiency of the intervention strategies in reducing the disease burden. In this work, we propose a mathematical model to describe the disease transmission mechanism between the individuals. We consider the initial phase of the outbreak situation in India and our proposed model is fitted to the daily cumulative new reported cases during the period $2^{nd}$ March, 2020 to $24^{th}$ March, 2020. We estimate the basic reproduction number $(R_0)$, effective reproduction number (R(t)) and epidemic doubling time from the incidence data for the above-mentioned period. We further assess the effect of preventive measures such as spread of awareness, lock-down, proper hand sanitization, etc. in reducing the new cases. Two intervention scenarios are considered depending on the variability of the intervention strength over the period of implementation. Our study suggests that higher intervention effort is required to control the disease outbreak within a shorter period of time in India. Moreover, our analysis reveals that the strength of the intervention should be strengthened over the time to eradicate the disease effectively.

25 pages, 10 figures. https://www.sciencedirect.com/science/article/pii/S0022519321001338?via%3Dihub

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Cited by in corpus (3)

• Optimal test-kit based intervention strategy of epidemic spreading in heterogeneous complex networks
• A mechanistic model for airborne and direct human-to-human transmission of COVID-19: Effect of mitigation strategies and immigration of infectious persons
• What the reproductive number R_0 can and cannot tell us about COVID-19 dynamics