Stochastic Dynamics of Nanoparticle and Virus Uptake

Abstract

The cellular uptake of nanoparticles or viruses requires that the gain of adhesion energy overcomes the cost of plasma membrane bending. It is well known that this leads to a minimal particle size for uptake. Using a simple deterministic theory for this process, we first show that, for the same radius and volume, cylindrical particles should be taken up faster than spherical particles, both for normal and parallel orientations. We then address stochastic effects, which are expected to be relevant due to small system size, and show that, now, spherical particles can have a faster uptake, because the mean first passage time profits from the multiplicative noise induced by the spherical geometry. We conclude that stochastic effects are strongly geometry dependent and may favor spherical shapes during adhesion-driven particle uptake.

arXiv comment5 pages, 4 figures

References in corpus (6)

• Elastic deformation of a fluid membrane upon colloid binding
• Stability of adhesion clusters under constant force
• Contact Mechanics of a Small Icosahedral Virus
• Stochastic Dynamics of Nanoparticle and Virus Uptake
• Particle-based membrane model for mesoscopic simulation of cellular dynamics
• Tissue fusion over non-adhering surfaces

Cited by in corpus (8)

• Stochastic Dynamics of Nanoparticle and Virus Uptake
• How Influenza's Spike Motor Works
• Dynamics of particle uptake at cell membranes
• Wrapping pathways of anisotropic dumbbell particles by giant unilamellar vesicles
• Receptor-Mediated Endocytosis of a Cylindrical Nanoparticle in the Presence of Cytoskeleton Substrate
• Controlling Uncertainty of Empirical First-Passage Times in the Small-Sample Regime
• A tutorial for mesoscale computer simulations of lipid membranes: tether pulling, tubulation and fluctuation
• Concentration of Empirical First-Passage Times