A Recipe for State Dependent Distributed Delay Differential Equations
arXiv:1811.05930 · doi:10.3934/mbe.2019270
Abstract
We use the McKendrick equation with variable ageing rate and randomly distributed maturation time to derive a state dependent distributed delay differential equation. We show that the resulting delay differential equation preserves non-negativity of initial conditions and we characterise local stability of equilibria. By specifying the distribution of maturation age, we recover state dependent discrete, uniform and gamma distributed delay differential equations. We show how to reduce the uniform case to a system of state dependent discrete delay equations and the gamma distributed case to a system of ordinary differential equations. To illustrate the benefits of these reductions, we convert previously published transit compartment models into equivalent distributed delay differential equations.
arXiv comment28 pages
Cited by in corpus (4)
- Operon Dynamics with State Dependent Transcription and/or Translation Delays
- A continuation technique for maximum likelihood estimators in biological models
- Distributed Delay Differential Equation Representations of Cyclic Differential Equations
- A novel mathematical model of heterogeneous cell proliferation