Jamming by growth

Abstract

Growth in confined spaces can drive cellular populations through a jamming transition from a fluid-like state to a solid-like state. Experiments have found that jammed budding yeast populations can build up extreme compressive pressures (over 1MPa), which in turn feed back onto cellular physiology by slowing or even stalling cell growth. Using extensive numerical simulations, we investigate how this feedback impacts the mechanical properties of model jammed cellular populations. We find that feedback directs growth toward poorly-coordinated regions, resulting in an excess number of cell-cell contacts that rigidify cell packings. Cell packings posses anomalously large shear and bulk moduli that depend sensitively on the strength of feedback. These results demonstrate that mechanical feedback on the single-cell level is a simple mechanism by which living systems can tune their population-level mechanical properties.

arXiv comment4 pages, 3 figures, Pawel Gniewek and Carl Schreck are co-first authors

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Cited by in corpus (5)

• Analogies between growing dense active matter and soft driven glasses
• Mechanical feedback controls the emergence of dynamical memory in growing tissue monolayers
• Minimal cellular automaton model with heterogeneous cell sizes predicts epithelial colony growth
• Exact Results in Stochastic Processes with Division, Death, and Diffusion: Spatial Correlations, Marginal Entropy Production, and Macroscopic Currents
• Far from equilibrium dynamics of tracer particles embedded in a growing multicellular spheroid