Scalable Graphene Aptasensors for Drug Quantification

Abstract

Simpler and more rapid approaches for therapeutic drug-level monitoring are highly desirable to enable use at the point-of-care. We have developed an all-electronic approach for detection of the HIV drug tenofovir based on scalable fabrication of arrays of graphene field-effect transistors (GFETs) functionalized with a commercially available DNA aptamer. The shift in the Dirac voltage of the GFETs varied systematically with the concentration of tenofovir in deionized water, with a detection limit less than 1 ng/mL. Tests against a set of negative controls confirmed the specificity of the sensor response. This approach offers the potential for further development into a rapid and convenient point-of-care tool with clinically relevant performance.

7 pages, 2 figures

References in corpus (5)

• The Raman Fingerprint of Graphene
• Scalable production of high sensitivity, label-free DNA biosensors based on back-gated graphene field-effect transistors
• Towards Quantifying the electrostatic transduction mechanism in carbon nanotube molecular sensors
• Quantifying the effect of ionic screening with protein-decorated graphene transistors
• An aptamer-biosensor for azole class antifungal drugs

Cited by in corpus (1)

• Graphene-based analytical lab-on-chip devices for detection of viruses: A review