Polymer translocation under a pulling force: scaling arguments and threshold forces

Abstract

DNA translocation through nanopores is one of the most promising strategies for the next-generation sequencing technologies. Most part of experimental and numerical works has focused on polymer translocation biased by electrophoresis, where a pulling force acts on the polymer within the nanopore. An alternative strategy however is emerging, which uses optical or magnetic tweezers. In this case, the pulling force is exerted directly at one end of the polymer, which strongly modifies the translocation process. In this paper, we report numerical simulations of both linear and structured (mimicking DNA) polymer models, simple enough to allow for a statistical treatment of the pore structure effects on the translocation time probability distributions. Based on extremely extended computer simulation data, we : i) propose scaling arguments for an extension of the predicted translocation times $\tau \sim N^2{F}^{-1}$ over the moderate forces range; ii) analyze the effect of pore size and polymer structuration on translocation times $\tau$.

References in corpus (7)

• Nonequilibrium dynamics of polymer translocation and straightening
• Polymer translocation through a nanopore under a pulling force
• Passage Times for Polymer Translocation Pulled through a Narrow Pore
• Dynamics of end-pulled polymer translocation through a nanopore
• Using a Péclet Number for the Translocation of Polymer through a Nanopore to Tune Coarse-Grained Simulations to Experimental Conditions
• Quantification of tension to explain bias dependence of driven polymer translocation dynamics
• Amplitude and Frequency Spectrum of Thermal Fluctuations of A Translocating RNA Molecule

Cited by in corpus (8)

• Translational Mobilities of Proteins in Nanochannels: A Coarse-Grained Molecular Dynamics Study
• Translocation through a narrow pore under a puling force
• Reducing the variance in the translocation times by pre-stretching the polymer
• Polymer translocation through nanopore assisted by an environment of active rods
• Cost of diffusion: nonlinearity and giant fluctuations
• Force spectroscopy analysis in polymer translocation
• Nonlinear-Cost Random Walk: exact statistics of the distance covered for fixed budget
• Polymer translocation driven by longitudinal and transversal time-dependent end-pulling forces