Multiple scattering limit in optical microscopy
arXiv:1709.03386 · doi:10.1364/OE.25.028914
Abstract
Optical microscopy offers a unique insight of biological structures with a sub-micrometer resolution and a minimum invasiveness. However, the inhomogeneities of the specimen itself can induce multiple scattering of light and optical aberrations which limit the observation to depths close to the surface. To predict quantitatively the penetration depth in microscopy, we theoretically derive the single-to-multiple scattering ratio in reflection. From this key quantity, the multiple scattering limit is deduced for various microscopic imaging techniques such as confocal microscopy, optical coherence tomography and related methods.
18 pages, 7 figures
References in corpus (5)
- Measuring the Transmission Matrix in Optics : An Approach to the Study and Control of Light Propagation in Disordered Media
- Image Transmission Through an Opaque Material
- Smart optical coherence tomography for ultra-deep imaging through highly scattering media
- Characterization of the angular memory effect of scattered light in biological tissues
- Exploiting the Time-Reversal Operator for Adaptive Optics, Selective Focusing and Scattering Pattern Analysis
Cited by in corpus (8)
- Distortion matrix concept for deep optical imaging in scattering media
- Diffraction-limited axial scanning in thick biological tissue employing an aberration correcting adaptive lens
- Manifestation of aberrations in full-field optical coherence tomography
- Harnessing Forward Multiple Scattering for Optical Imaging Deep Inside an Opaque Medium
- Multi-Spectral Reflection Matrix for Ultra-Fast 3D Label-Free Microscopy
- Theory of Multiple Scattering Enhanced Single Particle Plasmonic Sensing
- A model for full-field optical coherence tomography in scattering media
- Machine Learning-Informed Scattering Correlation Analysis of Sheared Colloids