RNA Base Pairing Determines the Conformations of RNA Inside Spherical Viruses
arXiv:1707.09540 · doi:10.1103/PhysRevLett.119.188102
Abstract
Many simple RNA viruses enclose their genetic material by a protein shell called the capsid. While the capsid structures are well characterized for most viruses, the structure of RNA inside the shells and the factors contributing to it remain poorly understood. We study the impact of base pairing on the conformations of RNA and find that it undergoes a swollen coil to globule continuous transition as a function of the strength of the pairing interaction. We also observe a first order transition and kink profile as a function of RNA length. All these transitions could explain the different RNA profiles observed inside viral shells.
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Cited by in corpus (5)
- Geometrically Constrained Kinklike Configurations
- The effect of RNA stiffness on the self-assembly of virus particles
- Effect of the charge distribution of virus coat proteins on the length of packaged RNAs
- Self Consistent Field Theory of Virus Assembly
- Molecular dynamics characterization of the free and encapsidated RNA2 of CCMV with the oxRNA model