paper

Controlling light in complex media beyond the acoustic diffraction-limit using the acousto-optic transmission matrix

arXiv:1707.02421 · doi:10.1038/s41467-019-08583-6

Abstract

Studying the internal structure of complex samples with light is an important task, but a difficult challenge due to light scattering. While the complex optical distortions induced by multiple scattering can be effectively undone with the knowledge of the medium's scattering-matrix, this matrix is generally unknown, and cannot be measured with high resolution without the presence of fluorescent or absorbing probes at all points of interest. To overcome these limitations, we introduce here the concept of the acousto-optic transmission matrix (AOTM). Taking advantage of the near scattering-free propagation of ultrasound in complex samples, we noninvasively measure an ultrasonically-encoded, spatially-resolved, optical scattering-matrix. We demonstrate that a singular value decomposition analysis of the AOTM, acquired using a single or multiple ultrasonic beams, allows controlled optical focusing beyond the acoustic diffraction limit in scattering media. Our approach provides a generalized framework for analyzing acousto-optical experiments, and for noninvasive, high-resolution study of complex media.

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