Minimal Model of Directed Cell Motility on Patterned Substrates

Abstract

Crawling cell motility is vital to many biological processes such as wound healing and the immune response. Using a minimal model we investigate the effects of patterned substrate adhesiveness and biophysical cell parameters on the direction of cell motion. We show that cells with low adhesion site formation rates may move perpendicular to adhesive stripes while a those with high adhesion site formation rates results in motility only parallel to the substrate stripes. We explore the effects of varying the substrate pattern and the strength of actin polymerization on the directionality of the crawling cell; these results have applications in motile cell sorting and guiding on engineered substrates.

arXiv comment13 pages, 3 figures

References in corpus (5)

• A minimal physical model captures the shapes of crawling cells
• Crawling and turning in a minimal reaction-diffusion cell motility model: coupling cell shape and biochemistry
• Effective adhesion strength of specifically bound vesicles
• On an evolution equation in a cell motility model
• Uniqueness and traveling waves in a cell motility model

Cited by in corpus (3)

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• Dynamics of a cell motility model near the sharp interface limit
• Cell mechanics, environmental geometry, and cell polarity control cell-cell collision outcomes