In situ coherent diffractive imaging

Abstract

Coherent diffractive imaging (CDI) has been widely applied in the physical and biological sciences using synchrotron radiation, XFELs, high harmonic generation, electrons and optical lasers. One of CDI's important applications is to probe dynamic phenomena with high spatio-temporal resolution. Here, we report the development of a general in situ CDI method for real-time imaging of dynamic processes in solution. By introducing a time-invariant overlapping region as a real-space constraint, we show that in situ CDI can simultaneously reconstruct a time series of the complex exit wave of dynamic processes with robust and fast convergence. We validate this method using numerical simulations with coherent X-rays and performing experiments on a materials science and a biological specimen in solution with an optical laser. Our numerical simulations further indicate that in situ CDI can potentially reduce the radiation dose by more than an order of magnitude relative to conventional CDI. As coherent X-rays are under rapid development worldwide, we expect in situ CDI could be applied to probe dynamic phenomena ranging from electrochemistry, structural phase transitions, charge transfer, transport, crystal nucleation, melting and fluid dynamics to biological imaging.

19 pages, 5 figures

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• Quantitative Imaging of Single, Unstained Viruses with Coherent X-rays
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Cited by in corpus (7)

• Large-scale phase retrieval
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• A semi-implicit relaxed Douglas-Rachford algorithm (sir-DR) for Ptychograhpy
• Bayesian multi-exposure image fusion for robust high dynamic range ptychography
• Data-driven discovery of dynamics from time-resolved coherent scattering
• Investigating the Limits of Hard X-ray Coherence Length Measurement Employing Young's Double Slit Experiment