Generic transport mechanisms for molecular traffic in cellular protrusions

Abstract

Transport of molecular motors along protein filaments in a half-closed geometry is a common feature of biologically relevant processes in cellular protrusions. Using a lattice gas model we study how the interplay between active and diffusive transport and mass conservation leads to localised domain walls and tip localisation of the motors. We identify a mechanism for task sharing between the active motors (maintaining a gradient) and the diffusive motion (transport to the tip), which ensures that energy consumption is low and motor exchange mostly happens at the tip. These features are attributed to strong nearest-neighbour correlations that lead to a strong reduction of active currents, which we calculate analytically using an exact moment-identity, and might prove useful for the understanding of correlations and active transport also in more elaborate systems.

arXiv comment5 pages, 3 figures, and Supplemental Material

References in corpus (25)

• Nonequilibrium Steady States of Matrix Product Form: A Solver's Guide
• Non-equilibrium statistical mechanics: From a paradigmatic model to biological transport
• Phase Coexistence in Driven One Dimensional Transport
• The Totally Asymmetric Simple Exclusion Process with Langmuir Kinetics
• Traffic of molecular motors through tube-like compartments
• Localization of shocks in driven diffusive systems without particle number conservation
• Two-Channel Totally Asymmetric Simple Exclusion Processes
• Matrix representation of the stationary measure for the multispecies TASEP
• Spontaneous Symmetry Breaking in Two-Channel Asymmetric Exclusion Processes with Narrow Entrances
• Asymmetric Coupling in Two-Channel Simple Exclusion Processes
• Traffic jams induced by rare switching events in two-lane transport
• Asymmetric coupling in two-lane simple exclusion process with Langmuir kinetics: phase diagrams and boundary layers
• Phase diagram of two-lane driven diffusive systems
• Molecular motor traffic in a half-open tube
• Shock-dynamics of two-lane driven lattice gases
• Molecular Mechanisms for Microtubule Length Regulation by Kinesin-8 and XMAP215 Proteins
• Driven Transport on Parallel Lanes with Particle Exclusion and Obstruction
• Domain wall delocalization, dynamics and fluctuations in an exclusion process with two internal states
• Multilane driven diffusive systems
• Traffic Jams and Shocks of Molecular Motors inside Cellular Protrusions
• Inhomogeneous Coupling in Two-Channel Asymmetric Simple Exclusion Processes
• A nonequilibrium diffusion and capture mechanism ensures tip-localization of regulating proteins on dynamic filaments
• Will jams get worse when slow cars move over?
• Modelling the effect of myosin X motors on filopodia growth
• Coupling driven exclusion and diffusion processes on parallel lanes: boundary induced phase transitions and boundary layers

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• Two-species active transport along cylindrical biofilaments is limited by emergent topological hindrance
• Interference of two co-directional exclusion processes in the presence of a static bottleneck: a biologically motivated model
• Self-organized system-size oscillation of a stochastic lattice-gas model
• Length control of long cell protrusions: rulers, timers and transport
• A Multispecies Exclusion Process with Fusion and Fission of Rods: a model inspired by Intraflagellar Transport
• Nonequilibrium steady states in coupled asymmetric and symmetric exclusion processes
• Reactions, Diffusion and Volume Exclusion in a Heterogeneous System of Interacting Particles
• Correlations and transport in exclusion processes with general finite memory
• Topology-dependent density optima for efficient simultaneous network exploration
• A biologically motivated three-species exclusion model: effects of leaky scanning and overlapping genes on initiation of protein synthesis
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