A MoS2-based capacitive displacement sensor for DNA sequencing

Abstract

We propose an aqueous functionalized molybdenum disulfide nanoribbon suspended over a solid electrode as the first capacitive displacement sensor aimed at determining the DNA sequence. The detectable sequencing events arise from the combination of Watson-Crick base-pairing, one of nature's most basic lock-and-key-binding mechanisms, with the ability of appropriately sized atomically thin membranes to flex substantially in response to sub-nanonewton forces. We employ carefully designed numerical simulations and theoretical estimates to demonstrate excellent (79 % to 86 %) raw target detection accuracy at ~70 million bases per second and electrical measurability of the detected events. In addition, we demonstrate reliable detection of repeated DNA motifs. Finally, we argue that the use of a nanoscale opening (nanopore) is not requisite for the operation of the proposed sensor and present a simplified sensor geometry without the nanopore as part of the sensing element. Our results therefore potentially suggest a realistic, inherently base-specific, high-throughput electronic DNA sequencing device as a cost-effective de-novo alternative to the existing methods.

arXiv comment28 pages, 8 figures

References in corpus (11)

• Canonical sampling through velocity-rescaling
• Separable Dual Space Gaussian Pseudo-potentials
• Relativistic separable dual-space Gaussian Pseudopotentials from H to Rn
• Graphene: A sub-nanometer trans-electrode membrane
• DNA Translocation through Graphene Nanopores
• Physical approaches to DNA sequencing and detection
• Molecular Dynamics Simulations of Single-Layer Molybdenum Disulphide (MoS2): Stillinger-Weber Parametrization, Mechanical Properties, and Thermal Conductivity
• Elastic Bending Modulus of Single-Layer Molybdenum Disulphide (MoS2): Finite Thickness Effect
• Nucleobase-functionalized graphene nanoribbons for accurate high-speed DNA sequencing
• Rippling, buckling and melting of single- and multi-layer MoS${}_2$
• An integrated capacitance bridge for high-resolution, wide temperature range quantum capacitance measurements

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• Sensitive single-photon test of extended quantum theory with 2D hexagonal boron nitride
• Relaxation-limited electronic currents in extended reservoir simulations
• Nanopores in atomically thin 2D nanosheets limit aqueous ssDNA transport