Hydrodynamic collective effects of active proteins in biological membranes

Abstract

Lipid bilayers forming biological membranes are known to behave as viscous 2D fluids on submicrometer scales; usually they contain a large number of active protein inclusions. Recently, it has been shown [Proc. Nat. Acad. Sci. USA 112, E3639 (2015)] that such active proteins should in- duce non-thermal fluctuating lipid flows leading to diffusion enhancement and chemotaxis-like drift for passive inclusions in biomembranes. Here, a detailed analytical and numerical investigation of such effects is performed. The attention is focused on the situations when proteins are concentrated within lipid rafts. We demonstrate that passive particles tend to become attracted by active rafts and are accumulated inside them.

12 pages, 7 figures

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Cited by in corpus (7)

• Effective diffusion coefficient including the Marangoni effect
• Hydrodynamic lift of a two-dimensional liquid domain with odd viscosity
• Mechanochemical enzymes and protein machines as hydrodynamic force dipoles: The active dimer model
• Nonequilibrium Transport Induced by Biological Nanomachines
• Lateral diffusion induced by active proteins in a biomembrane
• Anomalous diffusion in viscoelastic media with active force dipoles
• Anomalous diffusion and transport by a reciprocal convective flow