Number of trials required to estimate a free-energy difference, using fluctuation relations

Abstract

The difference Delta F between free energies has applications in biology, chemistry, and pharmacology. The value of Delta F can be estimated from experiments or simulations, via fluctuation theorems developed in statistical mechanics. Calculating the error in a Delta F estimate is difficult. Worse, atypical trials dominate estimates. How many trials one should perform was estimated roughly in [Jarzynski, Phys. Rev. E 73, 046105 (2006)]. We enhance the approximation with information-theoretic strategies: We quantify "dominance" with a tolerance parameter chosen by the experimenter or simulator. We bound the number of trials one should expect to perform, using the order-infinity Renyi entropy. The bound can be estimated if one implements the "good practice" of bidirectionality, known to improve estimates of Delta F. Estimating Delta F from this number of trials leads to an error that we bound approximately. Numerical experiments on a weakly interacting dilute classical gas support our analytical calculations.

7 pages (5 figures). Published version. Added fail-safety analysis, discussion of quantum and classical settings, and comparisons with previous works

References in corpus (3)

• Rare events and the convergence of exponentially averaged work values
• On the work distribution for the adiabatic compression of a dilute classical gas
• A characteristic of Bennett's acceptance ratio method

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