Models, measurement and inference in epithelial tissue dynamics

Abstract

The majority of solid tumours arise in epithelia and therefore much research effort has gone into investigating the growth, renewal and regulation of these tissues. Here we review different mathematical and computational approaches that have been used to model epithelia. We compare different models and describe future challenges that need to be overcome in order to fully exploit new data which present, for the first time, the real possibility for detailed model validation and comparison.

arXiv comment20 pages, 3 figures. To appear in Mathematical Biosciences and Engineering (in press)

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• Collective chemotaxis through noisy multicellular gradient sensing
• Sense and sensitivity: physical limits to multicellular sensing, migration and drug response
• Effects of cell-cell adhesion on migration of multicellular clusters